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Glycosylation inhibiting factor

abbr. GIF (a term with multiple meanings). GIF (abbr. in databanks also: GLIF) is involved in the regulation of IgE synthesis and inhibits the assembly of N-linked oligosaccharides to IgE-binding factors during their biosynthesis. This 13 kDa peptide is secreted in a bioactive form by suppressor T-cells; various human and murine cell line cells secrete an inactive form into the conditioned medium. The bioactive and inactive forms have the same amino acid sequence and appear to differ in posttranslational modifications. GIF is 98 % homologous with human MIF ( ... ... ... ... ... Subscribe to continue reading! ... ...

 

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