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Glyceraldehyde-3-phosphate dehydrogenase

abbr. GAPDH, which is also the approved gene symbol; abbr. also: GPD, GAPD, G3PD. This enzyme (EC1.2.1.12) catalyzes the conversion of glyceraldehyde-3-phosphate to 1,3-diphosphoglycerate and thus is a key enzyme in intermediary metabolism. Mammalian enzymes are structurally closely related (Nagradova and Grozdova, 1974). Glyceraldehyde-3-phosphate dehydrogenase is expressed widely in many tissues (Barber et al, 2005).

The enzyme is a tetrameric molecule of four identical subunits (36 kDa), each of which binds one molecule of the NAD+ cofactor (Reisler et al, 1975). Enzymes consisting of subunits of different species ... ... ... ... ... Subscribe to continue reading! ... ...


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