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Gemtuzumab ozogamicin

(available under the trade name Mylotarg). This is a calicheamicin-conjugated humanized murine monoclonal antibody directed against the CD antigen CD33. The antibody has been approved for cell depletion therapy in acute myeloid leukaemia patients. Binding and endocytosis of the antibody by leukaemia cells is followed by intracellular release of calicheamycin and disruption of DNA synthesis causing cell death (Bross et al, 2001; Pagano et al, 2007; Duong and Sekeres, 2009). The antibody has proven effective and relatively safe as a single agent in advanced acute promyelocytic leukemia (Breccia and Lo-Coco, 2011).

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