Granzymes |
GRAP2 |
menotropin |
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(approved gene symbol) [GRB2-related adaptor protein] The cDNA for this protein (217 amino acids) has been identified by Feng et al (1996) from a human cDNA library derived from early embryos and tonsils. GRAP is expressed primarily in thymus and spleen.
GRAP shows sequence similarity with GRB2, Caenorhabditis elegans Sem-5, and Drosophila melanogaster DARK. The protein contains a central SH2 domain flanked by two SH3 domains.
In vitro, the SH2 domain of GRAP interacts with the activated receptor for SCF, kit
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