GM-CSF |
GM-CSF augmenter |
Familial exudative vitreoretinopathy |
||
abbr. GIF (a term with multiple meanings). abbr. vGM-CSF/IL2BP. This factor is encoded by an open reading frame in the genome of the parapoxvirus orf virus (gene ORFV117; hence: orf virus ORFV117 protein; orf virus GM-CSF and IL2-inhibitory factor). The gene is expressed as an intermediate-late viral gene in orf virus-infected cells.
The viral protein forms homodimers and tetramers in solution and functions as a soluble protein inhibitor of ovine GM-CSF and IL2 and binds ovine GM-CSF with a K(d) of 369 pM and ovine IL2
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