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GIFT15 B(reg) cells

GIFT15 B(reg) cells (Rafei et al, 2009) are suppressive regulatory B-cells obtained by ex vivo treatment of mouse splenocytes with a fusion protein combining GM-CSF and IL15. These cells arise from CD19(+) B-cells, express major histocompatibility complex class I (MHCI) and MHCII, surface IgM and IgD, and secrete IL10, but lose expression of the transcription factor PAX5, coupled to upregulation of CD138 and reciprocal suppression of CD19. Mice with experimental autoimmune encephalomyelitis go ... ... ... ... ... Subscribe to continue reading! ... ...

 

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