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GFRAL

(approved gene symbol) [GDNF family receptor-alpha-like]. A data bank synonym is C6orf144 [chromosome 6 open reading frame 144].

The receptor has been identified by Li et al (2005) who referred to it as GRAL [GDNF receptor-alpha-like], and identified two splice variants, GRAL-A, and GRAL-B. Expression is seen primarily in the central nervous system. Overexpression of GRAL-A protects PC12 cells and cultured hippocampal neurons from serum starvation-induced cell death by apoptosis.

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