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GF-D8

A human myeloid leukemia cell line established from the peripheral blood of an 82-year-old man suffering from acute myeloblastic leukemia. GF-D8 cells are myeloblasts of immature progenitor origin (Rambaldi et al, 1993).

The cells differentiate in response to phorbol 12-myristate 13-acetate. Long-term survival and proliferation of GF-D8 cells is dependent on the presence of either GM-CSF or IL3 (see also: Factor-dependent cell lines). Weak colony growth is observed also after exposure of GF-D8 cells to SCF (stem cell factor) but not after exposure to G-CSF, ... ... ... ... ... Subscribe to continue reading! ... ...

 

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