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GAS Mac protein

[Group A Streptococcus Mac protein] This protein is secreted by Group A Streptococcus and acts as a virulence factor that enhances pathogen survival, establishment of infection and dissemination. The protein is a homolog of CD11b (Mac-1) that binds to CD16 on the surface of human polymorphonuclear leukocytes and inhibits opsonophagocytosis and production of reactive oxygen species, which results in significantly decreased pathogen killing (Lei et al, 2001).

For other relevant entries see also the Pathogenicity/Virulence Factors Dictionary section of this encyclopedia.

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