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Fusokines

[ Fusokine]

The term Fusokines has been used for recombinant cytokines / chemokines formed by recombining two cytokines or growth factors in a single molecule. Such molecules may have greater bioavailability and therapeutic potential than individual cytokines or a combination of different cytokines. Sanchez-Lugo et al (2015) have reported, for example, that a construct fusing the two chemokines CXCL10 / XCL1 elicit a greater chemotactic effect in lymphocytes stimulated by IL2 than individual or combined cytokines in vitro. This construct also is active in vivo as shown by intratumoral chemoattraction of cells ... ... ... ... ... Subscribe to continue reading! ... ...

 

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