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Fulicin

This pentapeptide containing a D-amino acid residue (Phe-D-Asn-Glu-Phe-Valamide; FNEFV) has been purified from the central ganglia of the African giant snail Achatina fulica Ferussac (Ohta et al, 1991). Fulicin potentiates tetanic contraction of the penis retractor muscle of this snail and also shows modulatory actions on the activity of the buccal and ventricular muscles and the central ganglionic neurons. Yasuda-Kamatani et al (1995) have cloned the cDNA for the Fulicin precursor and shown that the gene is expressed in central ganglia and also in the ventricles and atria. Fulicin serves not only as a neurotransmitter or neurohormone but also as a novel atrial hormone ... ... ... ... ... Subscribe to continue reading! ... ...

 

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