Foot-and-Mouth Disease Virus 3C protease

this cysteine proteases is encoded in the genome of Foot-and-Mouth Disease Virus. Wang D et al (2012) have reported that 3C protease cleaves NEMO [NF-kappa-B essential modulator], a component of the NF-kappa-B transcriptional complex. The inactivation of NEMO blocks innate immune responses involving RIG-I and MDA-5 that are activated by viral infections and culminate in the production of interferons. Du Y et al (2014) have reported that the viral protease also significantly reduces the transcript levels of interferon-stimulated genes by interfering with the JAK-STAT ... ... ... ...
 
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Entry last modified: September 2023