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Fibroblast growth factor binding proteins

The three binding proteins for fibroblast growth factors have been named FGFBP1, FGFBP2, FGFBP3 (Hanneken et al, 1994). All three proteins are truncated forms of the high-affinity FGF receptor (FGFR1) found in human plasma and calf serum. FGFBP1 (70-85 kDa) and FGFBP2 (55-60 kDa) are proteins derived from the extracellular domain of FGFR1 and bind bFGF. FGFBP2 and FGFBP3 consist of the extracellular domain of the two-IgG-loop form of human FGFR1.

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