Fastatin
This is derived from the fourth FAS1 domain (fasciclin-1 domain) of Beta-IG-H3 [TGF-beta-inducible gene H3] (Nam et al, 2005). Fastatin inhibits adhesion and migration of endothelial cells to Beta-IG-H3, fibronectin, and vitronectin. The RGD sequence that can serve as a ligand recognition site for several integrins is required.
Fastatin suppress endothelial cell tube formation and in vivo neovascularization in a Matrigel plug assay. The antiangiogenic activity of fastatin is associated with antitumor activity in mouse tumor models.
Fastatin also induces cell death by apoptosis
...
...
...
...
... Subscribe to continue reading!
... ...
Content view restricted !
COPE - with 54500+ entries the most comprehensive cell-to-cell communication knowledge base
Extensive In-depth and In Context Information covering terminology,
nomenclature, concepts, strategies & complexities of cellular communication, including
Acute phase proteins |
Angiogenesis |
Antimicrobial & host defense peptides |
Apoptosis & other forms of cell death |
CD antigens |
Cell lines |
Cell reprogramming |
Chemokines |
Cryptides |
Cytokines & Growth factors |
CytokineTopics |
Eukaryotic cell types & expression profiles |
Hematopoiesis |
Hormones |
Inflamation & inflammatory mediators |
Innate Immunity |
Metalloproteinases |
Microvesicles / Microparticles |
Moonlighting proteins & cryptides |
Neuropeptides |
Non-coding RNAs |
Pathogenicity & Virulence Factors |
Pattern recognition receptors |
Peptide sequences |
Protein domains |
Regulatory peptide factors |
Viroceptors |
Virokines and more.
Full COPEing for subscribers:
Access to Alphabet bar, Freetext search, Leafing/browsing functions, Internal Backlinking,
Topic-specific introductions, Topic-specific integrated subdictionaries, Scientific references with PubMed links
with a 15 USD/month subscription at
Cells-Talk.com
See example pages at the bottom of the Cells-Talk.com home page
THE SMART ONES COPE
The others just sisyphos around
|
ENTRY LAST MODIFIED: October 2005
| # |
A |
B |
C |
D |
E |
F |
G |
H |
I |
J |
K |
L |
M |
N |
O |
P |
Q |
R |
S |
T |
U |
V |
W |
X |
Y |
Z |
U L T R A P O S S E
N E M O O B L I G A T U R
cope.cgi Version 1.41 [08.12.2020]. (c) JI. Powered by Perl 5.032001. key=18426