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Fastatin

This is derived from the fourth FAS1 domain (fasciclin-1 domain) of Beta-IG-H3 [TGF-beta-inducible gene H3] (Nam et al, 2005). Fastatin inhibits adhesion and migration of endothelial cells to Beta-IG-H3, fibronectin, and vitronectin. The RGD sequence that can serve as a ligand recognition site for several integrins is required.

Fastatin suppress endothelial cell tube formation and in vivo neovascularization in a Matrigel plug assay. The antiangiogenic activity of fastatin is associated with antitumor activity in mouse tumor models.

Fastatin also induces cell death by apoptosis ... ... ... ... ... Subscribe to continue reading! ... ...

 

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