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Factor Xa-Inhibiting Peptide

This peptide with the sequence Thr-Asn-Gly-Tyr-Thr (TNGYT) has been isolated from the venom of the centipede Scolopendra subspinipes mutilans. The peptide inhibits the activity of Factor Xa (see: factor X). It prolongs the partial thromboplastin time and prothrombin time in both in vitro and ex vivo assays. It also significantly prolongs whole blood clotting time and bleeding time in mice.

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