FLS |
FLSAIASMLGKFL |
IL20 receptor-2 |
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FLS4.1 is a stromal cell line derived from 15-day fetal liver of BALB/c embryos. The cells synthesize mRNA for SCF but not for IL1, IL2, IL3, IL4, IL5, IL6, and IL7.
In the presence of IL7 these cells efficiently support the cloning and long-term growth of nontransformed pro-B-lymphocytes (Ig genes in germline configuration) and pre-B-cells (JH-rearranged genes with both light-chain Ig genes in the germline state) (see also: hematopoiesis). Clones of pro-B-lymphocytes can proliferate also in the presence of IL3
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