FLIPr |
FLIP-S |
E-CSF |
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[FPR-like1 inhibitory protein like] This secreted protein of Staphylococcus aureus has been identified by Prat et al (2009). The protein shows 73 % overall homology to FLIPr. FLIPr-like specifically binds to the FPR and FPRL1 receptors. FLIPr-like inhibits neutrophil calcium mobilization and chemotaxis induced by the FPRL1 ligand MMK-1 and FPR ligand fMLP. Its FPRL1 inhibitory activity lies in the comparable nanomolar range of FLIPr. Its antagonism of the FPR receptor is approximately 100-fold more potent than that of FLIPr and comparable to that of CHIPS.
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