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F8/G253 antigen

The two monoclonal antibodies F8 and G253 recognize a cell surface glycoprotein that is expressed with restricted distribution pattern in normal fetal and adult tissues (Rettig et al, 1988). Its expression is upregulated following malignant transformation in some cell types. The gene encoding this antigen has been cloned by Campbell et al (1994). It is identical with BCAM and the new designation for this antigen is CD239.

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