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F cells

this term is being used also to describe a subpopulation of erythrocytes that, during human development, have not completed the switch from fetal gamma-hemoglobin to adult beta-globin and therefore continue to produce HbF [fetal hemoglobin] (Rochette et al, 1994).

Cells that contain HbF survive longer in circulation than non-F-cells (Dover et al, 1978). Sickle cell disease patients with higher HbF levels usually have a milder clinical course (Stevens et al, 1981).

Perumbeti et al (2009) have shown that lentiviral delivery of the human gamma-globin gene under beta-globin regulatory control elements in hematopoietic stem cells ... ... ... ... ... Subscribe to continue reading! ... ...

 

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