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Ephrin A1b

Ephrin A1b is a splice variant of ephrin A1 described originally by Holzman et al (1999). Ephrin A1b (Finne et al, 2004) lacks a segment of 22 amino acids (residues 131-152 of Ephrin A1). Soluble EphA2 receptor binds weakly to ephrin A1b but binds strongly to ephrin A1a. Regulated cleavage of ephrins, which is known to occur after interaction with their receptors is inhibited by co-expression of ephrin A1a and ephrin A1b. Ephrin A1b thus may regulate the function of its ephrin A1a counterpart. See also: Ephrins.

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