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Endothelial cell-derived growth factor

abbr. ECDGF (a term with multiple meanings). This biochemically uncharacterized factor of approximately 10-30 kDa is found in the conditioned medium of bovine aortic endothelial cells (Gajdusek and Schwartz, 1984). The factor is not identical with PDGF. Heparin, dextran sulfate, and carageenan rapidly release non-PDGF-like ECDGF from BAE cell monolayers. The non-PDGF-like mitogen is associated with endothelial cell surfaces in contrast to the apparent constitutive release of PDGF-like mitogens (Gajdusek, 1984; Gajdusek and Schwartz, 1984).

ECDGF stimulates the growth of smooth muscle cells and mouse 3T3 ... ... ... ... ... Subscribe to continue reading! ... ...


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