Educated osteoblasts

this term has been used to refer to subsets of osteoblasts in metastatic breast cancer (for context compare also: educated cells). The phenotype of these cells differs from ordinary osteblasts. Educated osteoblasts suppress both triple-negative and estrogen receptor-positive breast cancer cell proliferation and increase cancer cell p21 expression. These effects are mediated by CCN3 (nov [Nephroblastoma overexpressed gene]) and decorin. In a mouse model, the presence of educated osteoblast in the tibia of tumor-bearing mice leads to increased amounts of alkaline phosphatase and suppresses the expression of inflammatory cytokines ... ... ... ...
 
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Entry last modified: March 2024