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This epithelioid sarcoma cell line has been established from a 44-year-old woman with recurrence and metastasis. The cells are positive for cytokeratin and vimentin (Kusakabe et al, 1993).

The conditioned medium of these cells contains high levels of IL6. Recombinant IL6 augments the proliferation of these cells, while antibodies against IL6 inhibit cell growth. The cells also express IL6 receptors, suggesting the existence of an autocrine loop.

The cell line does not express P-glycoprotein (CD243; MDR-1 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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