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EPO-X4

[Endogenous Peptide Inhibitor of CXCR4] EPO-X4 peptide is a 16-residue fragment of human serum albumin isolated originally as an inhibitor of CXCR4-tropic human immunodeficiency virus type 1 from a blood-derived peptide library. The peptide corresponds to albumin(408-423) of human serum albumin and has the sequence LVRYTKKVPQVSTPTL. Cathepsin D and Cathepsin E efficiently generate EPI-X4 from albumin under acidic conditions, i.e. conditions that are characteristic for sites of inflammation and tumor tissues (for related fragments see below).

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