EIA |
EICADPKQKWVQ |
thrombospondin type 1 domain containing 4 |
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[Equine infectious anemia virus S2 protein] This protein is encoded by Equine infectious anemia virus, a lentivirus that shows tropism for macrophages. EIAV S2 protein is a small auxiliary protein S2 from a short open reading frame that overlaps the amino terminus of env EIAV. S2 is approximately 7 kDa and has no overall amino acid sequence homology to other cellular or viral proteins. The protein is dispensable for virus replication in cultured cells (Li F et al, 1998), but is a virulence determinant that is required for disease production (Li F et al, 2000, 2003; Fagerness AJ et al, 2006).
Covaleda et al (2010) have shown that EIAV infection markedly alters the expression pattern of a variety of pro-inflammatory cytokines and chemokines by macrophages
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