EGKPYWPPPFLPE |
EGL-9 |
Dogiel cells |
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[egg laying abnormal-1] EGL-1 is one of more than 40 genes that affect egg laying in Caenorhabditis elegans (Trent et al, 1983). The EGL-1 gene encodes a cell death initiator protein that belongs to a group of proteins called BH3-only proteins as they contain a single BH3 domain but not the other BCL2 homology domains found in members of the BCL2 family of proteins. This BH3 domain allows EGL-1 to interact with other proteins.
Gain-of-function mutations in EGL-1 cause the hermaphrodite-specific neurons to undergo programmed cell death. Loss-of-function EGL-1 mutations prevent somatic programmed cell death
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