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EB-PE

[embryoid body-derived primitive erythroid] This immortalized cell line was established after retroviral insertional mutation from in vitro-differentiated embryoid bodies of embryonic stem cells.

The cells show characteristics of normal primitive erythroid (EryP) lineage cells (see also: hematopoiesis), such as gene expression and growth factor dependency. EB-PE cells can differentiate further in culture.

bFGF has been shown to be a strong mitogen for these cells, and Epo is required for both proliferation and differentiation. The proliferative response to ... ... ... ... ... Subscribe to continue reading! ... ...

 

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