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Differentiation inducing factor for human monoblastic leukemia cells

This factor is found in the conditioned medium of a human cell line established from fibroblasts (Noda et al, 1991). It induces the differentiation of the human monocytic leukemia cell line U937 into monocytes and macrophages.

The sequence of the first 13 aminoterminal amino acids is identical with that of IL6 except for the absence of the N-terminal proline. The factor is most probably identical with IL6.

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