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Dephrin

Dephrin, encoded by gene CG1862, is the Drosophila ortholog of vertebrate and invertebrate axonal pathfinding proteins known as ephrins. Dephrin is a transmembrane ephrin with a unique N terminus and an ephrin B-like cytoplasmic tail. Dephrin binds and interacts with DEph, the Drosophila Eph-like receptor (see: ephrins). Dephrin and DEph are confined to different neuronal compartments. Loss of Dephrin or DEph causes the abberant exit of interneuronal axons from the CNS. Ectopic expression of Dephrin halts axonal growth.

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