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Dengue virus NS4A protein

[Dengue virus non-structural protein 4A]; abbr. DENV NS4A protein. This non-structural protein is encoded in the genome of Dengue virus. The protein has been reported to play a role in immune evasion. It subverts host innate immunity by associating with MAVS. This prevents binding of MAVS to RIG-I and subsequent activation of the interferon regulatory factor IRF3 and induction of type 1 interferon production (He Z et al, 2016).

For other relevant entries see also the Pathogenicity/Virulence Factors Dictionary section of this encyclopedia.

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Entry last modified: April 2022

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