Dengue virus NS3

[Dengue virus non-structural protein 3]; abbr. DENV NS3 protein. This non-structural protein is encoded in the genome of Dengue virus. Dengue virus NS3 is required for the proteolytic processing of Dengue virus nonstructural proteins (Falgout B et al, 1991).

The protein has been reported to play a role in immune evasion. A protease complex between Dengue virus NS3 and Dengue virus NS2B protein has been reported to inhibit type 1 interferon responses by cleaving STING [stimulator of interferon genes], an adaptor downstream of cytosolic DNA sensors that trigger interferon ... ... ... ...
 
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Entry last modified: April 2022