Death Defying Domain

abbr. DDD. This name has been given to the short sequence motif DNAD-DEVD-T (Ma et al, 2014) The hyphens denote caspase cleavage sites.

This sequence motif has been observed as a tandem pair in the cytoplasmid domain of Met, the transmembrane tyrosine kinase receptor for hepatocyte growth factor (HGF). Upon cleavage of this sequence motif by Caspase-3, the resulting DEVD-T peptide acts as a competitive inhibitor and entraps the active site of Caspase-3 akin to DEVD-CHO, which is a potent, synthetic inhibitor of Caspase-3 activity (see: ... ... ... ...
 
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Entry last modified: January 2014