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Dark microglia

[dark microglial cell, dark microglial cells]

This term pertains to a distinct phenotype of microglial cells found in high numbers in nonhomeostatic conditions (e. g., Alzheimer's disease pathology, aging, chronic stress, maternal immune activation model, fractalkine signaling deficiency). Although the exact relationship is not clear, for comparison see also: disease-associated microglia, Human Alzheimer’s microglia, Plaque-associated microglia.

These cells show a gene expression profile that differs from that of normal microglial cells and are found in various brain regions, where they are frequently seen interacting with blood vessels ... ... ... ... ... Subscribe to continue reading! ... ...

 

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