DSCAM

[Down syndrome cell adhesion molecule] Human DSCAM is a protein belonging to the immunoglobulin superfamily family. DSCAM is a type-1 transmembrane receptor that contains ten immunoglobulin domains and six fibronectin type-3 repeats in its extracellular domain (Yamakawa et al, 1998). It is overexpressed in the brains of Down syndrome patients and implicated in mental retardation (Saito et al, 2000). Xu Y et al (2011) have reported that mammalian DSCAM deletion in the mouse causes severe hydrocephalus, decreases motor function, and impairs motor learning ability, indicating that mammalian ... ... ... ...
 
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Entry last modified: August 2013