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DRAGON

[DRG11-responsive axonal guidance and outgrowth of neurite] DRAGON has been identified as a membrane-associated [glycosyl-phosphatidylinositol (GPI)-anchored] protein the expression of which is transcriptionally regulated by DRG11, a transcription factor expressed in embryonic dorsal root ganglion and dorsal horn neurons that has a role in the development of sensory circuits.

DRAGON shares high sequence homology with two other GPI-anchored membrane proteins known as RGM [repulsive guidance molecule] and is known also as RGMb. DRAGON and the related proteins are highly conserved among mammals, zebrafish, chicken, and Caenorhabditis elegans, but not Drosophila ... ... ... ... ... Subscribe to continue reading! ... ...

 

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