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DNLD

The N-acetylated DNLD-aldehyde, Ac-DNLD-CHO, is a potent and specific inhibitor of caspase-3 and is used, therefore, to probe an involvement of this caspase in cell death by apoptosis (Tanuma S et al, 2004; Yoshimori et al, 2007).


General note on chemical modifications: Practically all of the available caspase inhibitors, be they specific or pan-caspase inhibitors, come in chemically modified form. The introduction of an aldehyde group at the C-terminus of the short peptide sequences recognized by caspases ... ... ... ... ... Subscribe to continue reading! ... ...

 

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