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DNA fragmentation assays

[DNA fragmentation assay]

any kind of assay that reveals the presence of orderly DNA fragmentation, which is usually taken as an indication of cell death by apoptosis (see: TUNEL assay, Comet assay, DNA laddering, DNA diffusion assay). It should be noted that an orderly pattern of DNA fragmentation is observed also as a consequence of freezing even when caspases, the critical enzymes involved in apoptotic cell death, are blocked (Kok et al, 2002).

For other assays allowing detection of apoptotic cells see also: apoptosis assays. For other entries pertaining to cell death mechanisms see also the ... ... ... ... ... Subscribe to continue reading! ... ...

 

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