DEP domain

so named after three proteins in which it was observed first: Drosophila melanogaster dishevelled (and its vertebrate orthologs DVL1, DVL2, DVL3), Caenorhabditis elegans Egl-10 [egg-laying defective protein 10] and mammalian pleckstrin (Ponting and Bork, 1996; for overview see: Consonni et al, 2014).

By interacting with negatively charged lipids in the inner plasma membrane, the DEP domain participates in the recruitment of proteins to the plasma membrane, for example dishevelled (and its vertebrate orthologs DVL1, DVL2, ... ... ... ...
 
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Entry last modified: June 2021