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Cytomegalovirus UL40 protein

abbr. CMV UL40 protein, HCMV UL40 protein. This protein is encoded by an open reading frame of human cytomegalovirus. It is a pathogenicity factor that plays a role in immune evasion by protecting virus-infected cells from being recognised by NK-cells. Cytomegalovirus UL40 protein has been reported to upregulate the cell surface expression of the non-classical MHC class I molecule HLA-E, the ligand for the NK-cell inhibitory receptor CD94 (Tomasec P et al, 2000), and to protect against lysis by NK-cells (Tomasec P et al, 2000; Ulbrecht M et al, 2000). This effect may be enhanced by IFN-gamma (Cerboni C et al, 2001).

Ulbrecht M et al (2000) have reported that ... ... ... ...
 
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Entry last modified: May 2024



 
 
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