Cytomegalovirus UL128 protein

abbr. CMV UL128 protein, HCMV UL128 protein. This protein is encoded by open reading frame UL128 in the genome of human cytomegalovirus. UL128 encodes a putative chemokine homolog (Cha et al, 1996). The protein has been reported to block the migration and to downregulate chemokine receptor expression in monocytes (Straschewski et al, 2011). Gao et al (2013) have reported the opposite effect, showing that it induces the migration of peripheral blood mononuclear cells. The discrepancy may be due to N-terminal modifications of the chemokines resulting in different chemotactic behavior.

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Entry last modified: June 2015