Colostrinine |
Colton blood group |
SPWSPCSTSCGLGVSTRI |
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abbr. CIF (a term with multiple meanings). A biochemically uncharacterized factor isolated from human colostrum that inhibits the induction of IL2 in cell lines established from T-lymphocytes (Mandalapu et al, 1995).
In EL4 cells stimulated with PMA (see also: Phorbol esters), inhibition is the result of blocking the accumulation of IL2 mRNA. Antisera against TGF-beta neutralize 10 % or less of the CIF activity in human colostrum.
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