CILP2(153-171) |
CIM6PR |
C5a anaphylatoxin chemotactic receptor |
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[Ciona intestinalis metamorphosis gene 4] Ci-META4 (83 amino acids) has been discovered in the coelomic cells of the tunicate Ciona intestinalis (Transparent sea squirt; Ascidia intestinalis) and is thought to play a role in metamorphosis (Nakayama et al, 2002). Some features of the cDNA structure of Ci-META4 suggest that it might constitute a precursor for an antimicrobial peptide. A synthetic peptide comprising 19 N-terminal amino acid residues in the predicted mature region of Ci-META4 has been shown to act as a defense peptide that exhibits potent antimicrobial activity against Gram-positive bacteria and Gram-negative bacteria. The peptide shows no hemolytic activity toward human erythrocytes
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