Cancer-associated SCM-recognition, immunedefense suppression, and serine protease protection peptide |
cancer cell organoids |
40S RPSA |
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This proteoglycan of 24 kDa (see also: extracellular matrix) has been isolated from the murine adenocarcinoma MAC16 (Todorov et al, 1996). The factor was named provisionally PIF (proteolysis inducing factor) and is identical probably with LMF (lipid-mobilizing factor) (see also: ZAG [Zinc-alpha-2-glycoprotein].
Cancer cachectic factor produces cachexia in vivo by inducing catabolism of skeletal muscle. The factor is present also in urine of cachectic cancer patients, but absent from normal subjects, patients with weight loss due to trauma, and cancer patients with little or no weight loss.
Smith et al (1999) have suggested that PIF
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