Calphobindin-1 |
calponin homology domain |
Defcr7 |
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Calphostin C (alternative name: UCN-1028c) is a perylenequinone metabolite from the fungus Cladosporium cladosporioides (Kobayashi et al, 1989, 1989; Takao et al, 1989). Calphostin C is used widely because it selectively inhibits most isoforms of protein kinase C by competing at the binding site for diacylglycerol and phorbol esters (Bruns et al, 1991; Gopalakrishna et al, 1992; Kobayashi et al, 1989, 1989; Pollack and Kawecki, 1997; Gueded RC and Eriksson, 2007).
As an inhibitor of protein kinase C Calphostin C is used widely to study whether this enzyme is involved in signal transduction processes elicited by cytokines
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