Calcium oxalate crystal growth inhibitor protein
This protein was found in the conditioned media from primary cultures of mouse kidney cortical cells. The protein inhibits the growth of calcium oxalate crystals and, by functioning as a crystal growth inhibitory protein, may prevent the formation of kidney stones (Hoyer et al, 1995; Worcester and Beshensky, 1995).
The sequence of the N-terminal 21 amino acids of this protein match that of osteopontin, a phosphoprotein initially isolated from bone matrix (Worcester et al, 1992).
See also: Uropontin.
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