CXCL8 L1 |
CXCL8 L3 |
chromogranin A (352-372) |
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This fish CXC-Chemokine is one of three homologs related to mammalian CXCL8 (IL8) (Chen et al, 2013; van der Aa et al, 2010). Its expression has been reported to be restricted to cyprinids to date (Abdelkhalek et al, 2009; Chen et al, 2013). The protein is expressed constitutively in several organs and is chemotactic for fish phagocytes. The protein lacks an ELR motif known to be associated with a functional role in leukocyte chemotaxis in mammals, but this may not be a requirement in fish.
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