CTTGPCCRQCKLKPAGTTCWRTSVSSHYCTGRSCECPSYPG |
CTX |
CD22-beta |
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This peptide, termed Pep42 by the authors, has been identified by phage display library screening, using whole-cell panning against human melanoma cell line Me6652/4 (Kim et al, 2006). The peptide is homologous to the plasminogen sequence Ser759-Phe778 (plasminogen(759-778)).
CTVALPGGYVRVC is a cell-penetrating peptide that shows preferential internalization into melanoma cell line Me6652/4 versus the reference cell line Me6652/56 in a receptor-mediated process. The receptor has been identified as glucose-regulated protein-78 (GRP78), and uptake of the peptide
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