CSFV p7 protein |
CSH1 |
BCL2L5 |
||
This peptide has been identified by screening a phage display library for vascular-targeting peptides (Greig et al, 2010). CSGMARTKC retains its selectivity across species and targets the cardiac vasculature in the stroke-prone spontaneously hypertensive rat. When CSGMARTKC is linked to the antioxidant peptide gp91ds, which selectively inhibits assembly of NAD(P)H oxidase, thereby reducing superoxide production, this allows anti-oxidant therapy in vivo. Use of the targeted protein can significantly improve nitric oxide bioavailability and attenuate the time-dependent and progressive increase in systolic blood pressure in the stroke-prone spontaneously hypertensive rat.
... ... ... ... ... Subscribe to continue reading! ... ...
Content view restricted ! |