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CS5931

This protein corresponds to progranulin-1 from Ciona savignyi (Cs-pgrn-1 [Ciona savignyi progranulin-1]). CS5931 shares high homology with Ciona intestinalis granulin and is conserved during evolution. The polypeptide also shows high similarity with human Granulin A, Granulin B, and Granulin C (Zhao et al, 2013). Zhao et al (2013) have reported that the peptide causes cell death by apoptosis in several tumor cell lines. CS5931 causes cell cycle arrest at the G(2)/M phase and the mechanism of action involves intrinsic apoptosis (mitochondrial apoptosis) (Cheng L et al, 2012).

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