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CRPPR

This peptide, Cys-Arg-Pro-Pro-Arg, has been identified by Zhang et al (2005) by in vivo phage display selection. By sequence it is a member of the C-end Rule peptides group.

The peptide acts as a homing peptide that selectively targets heart endothelial cells. Zhang et al (2005) have identified CRIP2 [cysteine-rich protein 2] as a putative receptor expressed on heart endothelial cells. Zhang et al (2008) have reported that liposomes coated with this peptide home in to heart tissues. Greig et al (2010) have reported that the peptide retains its selectivity across species and targets the aorta in the stroke-prone spontaneously hypertensive rat. When the vascular-targeting ... ... ... ... ... Subscribe to continue reading! ... ...

 

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